Moreover, the starting point too contributes to the difference between leading and lagging strand. Hence, this is another difference between leading and lagging strand. Leading strand requires a single primer for the synthesis while the lagging strand requires a new primer to start each Okazaki fragment. Leading strand grows in the 5’ to 3’ direction while the lagging strand grows in the 3’ to 5’ direction. The direction of the Template in the Replication Forkįurthermore, another important difference between leading and lagging strand is that the leading strand opens up in the 3’ to 5’ direction while the lagging strand opens up in the 5’ to 3’ direction. Importantly, the leading strand grows continuously while the lagging strand grows discontinuously by forming Okazaki fragments. Thus, this is the main difference between leading and lagging strand. Leading strand refers to one of two strands of DNA found at the replication fork, being replicated continuously while lagging strand refers to the other strand found at the replication fork, replicating discontinuously in the 5′ to 3′ direction. Also, DNA polymerase is responsible for the synthesis of both leading and lagging strands.ĭifference Between Leading and Lagging Strand Definition.Furthermore, both strands are made up of DNA nucleotides, which link to each other through phosphodiester bonds.However, the leading and the lagging strand are complementary to each other.They are classified based on the pattern of replication.Leading and lagging strand are the two types of DNA strands found in the double-stranded DNA molecule.Similarities Between Leading and Lagging Strand Therefore, the process of DNA replication is known as a semiconservative process where each newly synthesized DNA double helix composes an old and a new DNA strand During the process, each strand of the DNA double helix serves as templates for replication. DNA polymerase is the enzyme that is responsible for DNA replication carried out exclusively in the 5’ to 3’ direction. Generally, DNA undergoes replication during the cell cycle as a step of preparing the cell for the division. Leading strand is one of the two strands of the DNA double helix. – Comparison of Key Differences Key TermsĭNA replication, Leading Strand, Lagging Strand, Okazaki Fragments, Replication Fork What is the Difference Between Leading and Lagging Strand What are the Similarities Between Leading and Lagging StrandĤ. – Definition, Type of Strand Growth, Importanceģ. Leading and lagging strand are two terms that we use to describe the two strands of the double-stranded DNA during DNA replication based on the pattern of strand growth. Furthermore, the leading strand opens in the 3’ to 5’ direction while the lagging strand opens in the 5’ to 3’ direction. Therefore, to form a continuous strand, the leading strand does not require ligase while the lagging strand requires ligase to ligate Okazaki fragments together. The main difference between leading and lagging strand is that the leading strand is the DNA strand, which grows continuously during DNA replication whereas lagging strand is the DNA strand, which grows discontinuously by forming short segments known as Okazaki fragments.
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